Fig. 4 | Scientific Reports

Fig. 4

From: An Andrias davidianus derived composite hydrogel with enhanced antibacterial and bone repair properties for osteomyelitis treatment

Fig. 4

The SOA hydrogel promoted osteogenic differentiation via the slow-release MSA-anti214 in vitro. miR-214-3p expression levels in hMSCs treated with A + P214 hydrogel and B the SOA separately at the specified intervals (compared with the + PNC/+PMNC hydrogel). CAlp and DRunx2 expression levels in hMSCs treated with the SOA hydrogel. E ALP and alizarin red staining of hMSCs treated long-term with the SOA hydrogel compared to those treated with the + PMNC hydrogel. ALP: results of ALP staining; ARS: results of alizarin red staining. F–G miR-214-3p expression levels in hMSCs after treated with serum-pretreated + P214 (Serum + P214) and SOA (Serum + SOA) hydrogels at the specified intervals. All quantitative data are presented as mean values ± standard deviation (n = 3, * p < 0.05, ** p < 0.01, *** p < 0.001, ns: no significance).

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