Fig. 5 | Scientific Reports

Fig. 5

From: An Andrias davidianus derived composite hydrogel with enhanced antibacterial and bone repair properties for osteomyelitis treatment

Fig. 5

Application of the SOA to treat osteomyelitis in a mouse model. A Schematic representation and experimental timeline for creating a mouse osteomyelitis model and SOA hydrogel treatment. B Blood procalcitonin (PCT) and C C-reactive protein (CRP) levels in mice after treatment with different hydrogels. Sham: sham Staphylococcus aureus model group; S. aureus: S. aureus model group; SSAD: SSAD-treated group; +HA: SSAD/HA-treated group; +Van: SSAD/HA + Van-treated group; +PVAm: SSAD/HA + Van + PVAm-treated; +PMNC: SSAD/HA + Van + PMNC-treated group; SOA: SSAD/HA + Van + PM214-treated group; Van: pure Van-treated group. D, E Soybean agar plates showing the antibacterial efficiency of different treatment groups against S. aureus in vivo and the corresponding antibacterial histograms. F CD68 immunohistochemical images of bone sections from each group. The G CD3 and H CD68 corresponding quantitative histograms. The black scale bar in the non-black box indicates 250 μm, and the black scale bar in the black box indicates 50 μm. All quantitative data are presented as mean values ± standard deviation (n = 3, * p < 0.05, ** p < 0.01, *** p < 0.001, ns: no significance).

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