Table 1 Top ten topological analysis of the PPI network based on three centrality algorithms.
Target name | Degree centrality | Target name | Betweenness centrality | Target name | Closeness centrality |
|---|---|---|---|---|---|
TP53 | 75 | TP53 | 0.185069 | TP53 | 0.520343 |
EGFR | 56 | IL6 | 0.088949 | EGFR | 0.492901 |
IL6 | 55 | EGFR | 0.0818 | IL6 | 0.486 |
HSP90AA1 | 50 | SRC | 0.071918 | SRC | 0.483101 |
TNF | 49 | PTGS2 | 0.0643 | GAPDH | 0.481188 |
STAT3 | 48 | TNF | 0.060704 | STAT3 | 0.478346 |
SRC | 45 | HSP90AA1 | 0.056621 | HSP90AA1 | 0.472763 |
GAPDH | 40 | ESR1 | 0.053633 | TNF | 0.47093 |
MAPK1 | 38 | GAPDH | 0.051498 | MAPK1 | 0.461977 |
CASP3 | 36 | STAT3 | 0.046388 | ESR1 | 0.453358 |
