Table 1 Pharmacological profile comparison of X. tropicalis Tmem16a with published data from human TMEM16A (abc and acd isoforms).

Ani9

0.098 ± 0.009 µM (13)

0.066 µM, human TMEM16Aacd⁶¹

52% inhibition at 0.05 µM, human TMEM16Aabc⁵⁸

0.068 µM, human TMEM16Aabc⁶⁵

CaCCinh_A01

12.91 ± 1.96 µM (9)

7.84 µM, human TMEM16A⁶²

7.57 µM, human TMEM16Aacd⁶³

1.7 µM, human TMEM16Aacd⁶⁰

Benzbromarone

3.30 ± 1.45 µM (10)

3.05 µM, human TMEM16Aabc⁶⁵

4.09 µM human TMEM16Aacd⁶³

2.35 µM, human TMEM16Aacd⁶⁴

Niflumic acid

85.12 ± 19.06 µM (4)

8.34 µM, human TMEM16Aacd⁶¹

12.1 µM, human TMEM16Aacd⁶⁰

8.54 µM human TMEM16Aacd⁶³

CFTR Inh-172

> 30 µM (5)

Idebenone

> 30 µM (4)

54% and 90% inhibition by 10 µM and 30 µM respectively, human TMEM16A⁶¹

MONNA

11.89 ± 3.45 µM (6)

13.60 µM human TMEM16Aacd⁶³

T16inh-A01

> 30 µM (6)

> 30 µM human TMEM16Aacd⁶³

1.51 µM, human TMEM16Aacd⁶⁰

9-AC

145.9 ± 65.8 µM (5)

57.7 µM, human TMEM16Aacd^60