Table 2 Multivariate analysis for overall survival and cancer–specific survival for total elderly differentiated thyroid cancer.
Variable | Differentiated thyroid carcinoma | |||
|---|---|---|---|---|
Overall survival | Thyroid cancer-specific survival | |||
Hazard ratio(95%CI) | p | Hazard ratio (95%CI) | p | |
Age | ||||
60–79 years | 1(Reference) | N/A | 1(Reference) | N/A |
≥ 80 years | 3.23 (2.87, 3.65) | < 0.001 | 2.33 (1.90, 2.87) | < 0.001 |
Classification | ||||
PTC | 1(Reference) | N/A | 1(Reference) | N/A |
FTC | 0.96 (0.82, 1.13) | 0.62 | 1.08 (0.84, 1.39) | 0.554 |
Sex | ||||
Male | 1(Reference) | N/A | 1(Reference) | N/A |
Female | 0.63 (0.57, 0.71) | < 0.001 | 0.83 (0.69, 1.01) | 0.06 |
T stage | ||||
T0 | 1(Reference) | N/A | 1(Reference) | N/A |
T1 | 0.98 (0.40, 2.40) | 0.96 | 0.50 (0.07, 3.67) | 0.49 |
T2 | 0.96 (0.38, 2.45) | 0.93 | 1.17 (0.15, 9.10) | 0.88 |
T3 | 1.09 (0.44, 2.71) | 0.86 | 1.89 (0.25, 14.23) | 0.54 |
T4 | 2.65 (1.06, 6.60) | 0.04 | 6.20 (0.82, 46.58) | 0.08 |
TX | 0.84 (0.33, 2.15) | 0.71 | 1.27 (0.16, 9.85) | 0.82 |
N stage | ||||
N0 | 1(Reference) | N/A | 1(Reference) | N/A |
N1 | 1.57 (1.37, 1.79) | < 0.001 | 2.29 (1.86, 2.83) | < 0.001 |
NX | 1.65 (1.27, 2.14) | < 0.001 | 1.83 (1.24, 2.69) | 0.00 |
M stage | ||||
M0 | 1(Reference) | N/A | 1(Reference) | N/A |
M1 | 2.41 (2.01, 2.88) | < 0.001 | 3.60 (2.85, 4.54) | < 0.001 |
Surgery of the primary | ||||
No | 1(Reference) | N/A | 1(Reference) | N/A |
Thyroidectomy | 0.41 (0.33, 0.51) | < 0.001 | 0.45 (0.31, 0.65) | < 0.001 |
Subtotal or near total thyroidectomy | 0.49 (0.35, 0.68) | < 0.001 | 0.84 (0.52, 1.36) | 0.48 |
Total thyroidectomy | 0.37 (0.30, 0.44) | < 0.001 | 0.39 (0.30, 0.51) | < 0.001 |
Surgery of other regional disease | ||||
No/unknown | 1(Reference) | N/A | 1(Reference) | N/A |
Yes | 1.32 (1.04, 1.67) | 0.02 | 1.58 (1.17, 2.14) | 0.00 |
Race | ||||
White | 1(Reference) | N/A | 1(Reference) | N/A |
Black | 1.23 (1.02, 1.48) | 0.03 | 0.76 (0.51, 1.13) | 0.17 |
Asian or Pacific Islander | 0.78 (0.65, 0.92) | 0.00 | 1.01 (0.78, 1.31) | 0.93 |
American Indian/Alaska Native | 1.53 (0.88, 2.65) | 0.13 | 2.00 (0.82, 4.86) | 0.13 |
Radiation | ||||
None/Unknown | 1(Reference) | N/A | 1(Reference) | N/A |
Radioisotopes | 0.58 (0.51, 0.65) | < 0.001 | 0.58 (0.46, 0.73) | < 0.001 |
Other radiation | 1.03 (0.84, 1.26) | 0.76 | 1.21 (0.93, 1.56) | 0.16 |
Chemotherapy | ||||
None/Unknown | 1(Reference) | N/A | 1(Reference) | N/A |
Yes | 1.83 (1.39, 2.40) | < 0.001 | 1.97 (1.43, 2.71) | < 0.001 |
Tumor size | ||||
≤ 1 cm | 1(Reference) | N/A | 1(Reference) | N/A |
> 1 and ≤ 2 cm | 1.22 (1.03, 1.44) | 0.02 | 1.23 (0.79, 1.91) | 0.37 |
> 2 and ≤ 4 cm | 1.59 (1.23, 2.06) | < 0.001 | 1.62 (0.99, 2.63) | 0.05 |
> 4 cm | 2.06 (1.62, 2.61) | < 0.001 | 2.27 (1.43, 3.59) | < 0.001 |
Unknown | 2.26 (1.67, 3.07) | < 0.001 | 3.46 (2.04, 5.86) | < 0.001 |
Marital status | ||||
Married | 1(Reference) | N/A | 1(Reference) | N/A |
Others | 1.31 (1.17, 1.45) | < 0.001 | 1.33 (1.10, 1.60) | 0.00 |
