Table 1 The demographic and baseline characteristics of participants. Continuous variables were reported as median [IQR]. Comparisons between groups using non-parametric Mann-Whitney test and chi-square test. p1 represents the p-value for the comparison between CAD and CAD-Controls. p2 represents the p-value for the comparison between HF and HF-Controls.

From: Cell-free plasma telomere length correlated with the risk of cardiovascular events using machine learning classifiers

 

Overall

CAD

CAD-Controls

p1

HF

HF-Controls

p2

n

514

201

313

 

164

350

 

Age

68.50 [62.00, 76.00]

71.00 [64.00, 78.00]

68.00 [61.00, 75.00]

0.001

74.50 [68.00, 79.00]

66.00 [60.00, 73.00]

< 0.001

cf-TL

3.70 [2.64, 5.11]

3.68 [2.81, 5.32]

3.72 [2.49, 5.00]

0.346

3.83 [2.98, 5.40]

3.65 [2.43, 5.01]

0.014

NOx

2.95 [2.55, 3.32]

2.95 [2.55, 3.36]

2.95 [2.56, 3.23]

0.751

3.05 [2.63, 3.44]

2.90 [2.50, 3.21]

0.002

BMI

27.15 [24.50, 30.10]

27.90 [25.50, 31.40]

26.50 [24.10, 29.70]

< 0.001

27.70 [25.40, 31.02]

26.85 [24.10, 30.00]

0.01

eGFR

79.00 [63.85, 91.47]

72.50 [55.70, 87.60]

82.81 [69.10, 92.00]

< 0.001

66.90 [52.30, 80.00]

84.15 [71.00, 92.88]

< 0.001

Hb

138.00 [130.00, 145.00]

138.00 [128.00, 145.00]

138.00 [130.00, 145.00]

0.741

134.00 [125.00, 141.00]

139.00 [132.00, 146.00]

< 0.001

HbA1C

5.75 [5.59, 6.10]

5.84 [5.50, 6.50]

5.72 [5.60, 5.98]

0.02

5.90 [5.60, 6.43]

5.70 [5.58, 6.00]

0.001

HDL_cholesterol

1.41 [1.17, 1.65]

1.33 [1.09, 1.55]

1.47 [1.22, 1.77]

< 0.001

1.38 [1.18, 1.57]

1.44 [1.17, 1.72]

0.036

Creatinine

78.16 [68.00, 92.00]

86.00 [76.00, 102.00]

74.00 [65.00, 85.00]

< 0.001

89.50 [75.00, 110.00]

74.16 [66.00, 85.00]

< 0.001

LDL_cholesterol

2.68 [1.93, 3.51]

2.08 [1.60, 2.64]

3.10 [2.48, 3.88]

< 0.001

2.20 [1.65, 2.88]

2.93 [2.21, 3.70]

< 0.001

Lipoprotein_a

7.29 [3.00, 39.50]

12.00 [3.79, 62.60]

6.17 [3.00, 24.41]

< 0.001

10.04 [3.25, 61.35]

6.54 [3.00, 31.22]

0.089

Total_cholesterol

4.56 [3.72, 5.45]

3.79 [3.23, 4.54]

5.09 [4.29, 5.79]

< 0.001

3.94 [3.37, 4.79]

4.89 [4.00, 5.63]

< 0.001

Triglycerides

1.23 [0.89, 1.83]

1.32 [0.96, 1.89]

1.20 [0.86, 1.75]

0.135

1.33 [0.96, 1.93]

1.19 [0.88, 1.78]

0.218

DBP

79.00 [71.00, 85.00]

76.00 [69.00, 84.00]

80.00 [73.00, 87.00]

< 0.001

76.69 [69.00, 84.00]

80.00 [73.00, 86.00]

0.004

SBP

139.00 [128.00, 150.00]

135.00 [125.00, 146.00]

141.00 [130.00, 152.00]

0.007

140.00 [127.00, 150.50]

138.00 [128.00, 149.00]

0.605

Male (%)

278 (54.09)

140 (69.65)

138 (44.09)

< 0.001

104 (63.41)

174 (49.71)

0.005

Smoking (%)

222 (43.19)

105 (52.24)

117 (37.38)

0.001

73 (44.51)

149 (42.57)

0.75

Diabetes (%)

104 (20.23)

55 (27.36)

49 (15.65)

0.002

47 (28.66)

57 (16.29)

0.002

Hypertension (%)

371 (72.18)

184 (91.54)

187 (59.74)

< 0.001

153 (93.29)

218 (62.29)

< 0.001

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