Fig. 5
From: Salbutamol attenuates arrhythmogenic effect of aminophylline in a hPSC-derived cardiac model
Contractile properties and beat rate variability analysis of hPSC-CMs with salbutamol, aminophylline, and selective β2-AR blocker butoxamine. Scatter plots indicate means and standard deviations (SD) of the beat rate and contraction force relative responses normalized to the respective baseline control measurement in the case of salbutamol and mixed treatments and to mean values of the control measurement. Scatter plots with means and SDs of SDSDs measured with mixed treatments and control means (n and P values) are presented in Table S1 in Supplementary data, ordinary one-way ANOVA test was used. (A, B) The contraction force and beat rate of EBs treated with the mixes of salbutamol, aminophylline, and butoxamine are indicated at the bottom. (C) Analysis of short-term variability SDSD. Control groups were always paired with treatment groups based on the time they were given, so they were repeated from previous figures. (D) Poincaré plots with SDSD. If butoxamine was added to the mix, contractile properties were not significantly different from the effect of aminophylline alone. The anti-arrhythmic potential of salbutamol completely diminished when butoxamine was co-administered.
