Fig. 4
Development and validation of the lactic acid metabolism-related prognostic models. (A) Intersection of DEGs of AML and lactate metabolism-associated genes. (B) Protein and protein interaction network of the 15 genes with the highest degrees. (C,D) The coefficient distribution of LASSO Cox regression analysis and adjustment parameters were calculated based on partial likelihood deviation and tenfold cross-validation. (E) The risk curve, survival status, and model gene expression levels of AML patients in different risk groups in the TCGA cohort. (F) Survival analysis between risk groups in the TCGA cohort. (G) The risk curve, survival status, and model gene expression levels of AML patients in different risk groups in GSE71014. (H) Survival analysis between risk groups in the GSE71014 dataset. (I,J) Univariate and multivariate analyses of the prognostic model genes. (K) Result of the decision curve analysis. (L–M) Prognostic correction curves and nomogram incorporating age, sex, and WBC count as variables.
