Figure 4
PPI network and key gene analysis. (A) Protein-protein internecion (PPI) DEGs from the STRING database are represented by connecting lines of different thicknesses to indicate the strength of association between proteins. (B) Module 1 consisted of 22 nodes and 200 edges. (C) Module 2 consisted of 12 nodes and 49 edges. (D) The transcription factors in the top 20 are ranked based on their P values and their interactions with DEGS. Within the network diagram, the red circles denote the transcription factors exhibiting the 20 lowest P values, whereas the yellow circles signify the differentially expressed genes that exhibit correlation with these transcription factors. (E) Utilize five topological algorithms to predict and explore the central genes involved in these networks, presenting the results in a Venn diagram.
