Fig. 6

Conclusive graphical abstract: The fungus was isolated from the sponge Amphimedon viridis. The fungal extract showed significant antiviral activity against COVID-19 (SARS-CoV-2 virus). Bio-active molecules of Aspergillus tamarii showed more potential activity than the repurposed drug (Remdesivir) through Docking, MD and MM-GPSA calculations. New anti-COVID-19 compounds were identified and isolated.