Table 1 Baseline patient characteristics.

From: Mechanism and significance of diffusion restriction followed by calcification in high-grade glioma treated with bevacizumab

Variable

Ā 

Calcification

Non-calcification

p value a

All patients

Ā 

17 (48.6%)

18 (51.4%)

Ā 

Age (years)

≄ 65

8 (47.1%)

7 (38.9%)

0.738

Ā 

< 65

9 (52.9%)

11 (61.1%)

Ā 

Sex

Male

9 (52.9%)

12 (66.7%)

0.500

Ā 

Female

8 (47.1%)

6 (33.3%)

Ā 

BVZ treatment

New diagnosis

10 (58.8%)

10 (55.6%)

> 0.999

Ā 

Recurrence

7 (41.2%)

8 (44.4%)

Ā 

WHO grade

3

8 (47.1%)

9 (50.0%)

> 0.999

Ā 

4

9 (52.9%)

9 (50.0%)

Ā 

IDH-1 mutation

Yes

4 (26.7%)

4 (23.5%)

> 0.999

Ā 

No

11 (73.3%)

13 (76.5%)

Ā 

MGMT protein expression

Present

10 (66.7%)

10 (58.8%)

0.708

Ā 

Absent

5 (33.3%)

7 (41.2%)

Ā 

Number of BVZ cycles

≄ 23

13 (76.5%)

6 (33.3%)

0.018

Ā 

< 23

4 (23.5%)

12 (66.7%)

Ā 

BCNU wafer implantation

Yes

8 (47.1%)

9 (50.0%)

> 0.999

Ā 

No

9 (52.9%)

9 (50.0%)

Ā 

Extent of resection

≄ 90%

6 (35.3%)

10 (55.6%)

0.315

Ā 

< 90%

11 (64.7%)

8 (44.4%)

Ā 
  1. aTwo-sided Fisher’s exact test.
  2. Abbreviations: BCNU, bis-chloroethyl nitrosourea; BVZ, bevacizumab; IDH-1, isocitrate dehydrogenase 1; MGMT, O6-methylguanine DNA methyltransferase; WHO, World Health Organization.