Fig. 6 | Scientific Reports

Fig. 6

From: TLR3 activation enhances antitumor effects of sorafenib in hepatocellular carcinoma by activating NK cell functions through ERK and NF-κB pathways

Fig. 6

The ERK and NF-κB pathways are involved in the poly(I: C)-induced activation of NK cells. Poly(I: C) attenuated sorafenib-mediated inhibition of ERK1/2 phosphorylation in liver cancer cells (A) and isolated NK cells (B). Liver cancer LM3-shTLR3 cells (A) or isolated NK cells (B) were treated with sorafenib (10 µM) without or with poly(I: C) for 24 h. ERK1/2 phosphorylation was determined by Western blotting. Representative images are shown. (C) Sorafenib did not significantly affect poly(I: C)-induced IκB phosphorylation in isolated human NK cells treated with poly(I: C) with or without sorafenib (10 µM) for 24 h. IκB phosphorylation was determined by Western blotting.

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