Fig. 4
From: Rac1 inhibition regenerates wounds in mouse fetuses via altered actin dynamics
Wound healing in adult epidermis-specific Rac1-knockout mice (K14-CreERT2;Rac1flox/flox). (a) Shema of K14-CreERT2;Rac1flox/flox mouse crosses. (b) Evaluation of Rac1 expression in the epidermis. TM: Tamoxifen. *P < 0.05. (c) Progression of wound healing in epidermis-specific Rac1-knockout mice. Tamoxifen treatment significantly prolongs epithelialization in epidermis-specific Rac1-suppressed mice. Scale bar = 1 cm. *P < 0.05. (d) Hematoxylin & eosin stained images of wound healing process in epidermis-specific Rac1-knockout mice. Scale bar = 100 μm. (e) Masson’s trichrome stained image of the wound healing process in epidermis-specific Rac1-knockout mice. Scale bar = 100 μm.
