Table 3 Sensitivity analysis for weighted association between depression and liver function biomarkers in US cancer survivors, by excluding participants with missing covariables.

From: Association between depression and liver function biomarkers among US cancer survivors in NHANES 2005–2020

Liver function biomarkers

Crude model

Model I

Model II

OR (95%CI)

P-value

OR (95%CI)

P-value

OR (95%CI)

P-value

ALT (U/L)

1.007 (1.000, 1.014)

0.047

1.007 (1.001, 1.013)

0.024

1.007 (1.001, 1.014)

0.024

AST (U/L)

1.004 (0.994, 1.014)

0.481

1.006 (0.998, 1.015)

0.155

1.004 (0.996, 1.013)

0.321

AST/ALT

0.596 (0.350, 1.013)

0.056

0.651 (0.379, 1.117)

0.118

0.565 (0.328, 0.974)

0.040

ALP (U/L)

1.006 (1.000, 1.013)

0.035

1.008 (1.002, 1.015)

0.014

1.006 (1.002, 1.011)

0.009

GGT (U/L)

1.006 (1.003, 1.009)

 < 0.001

1.006 (1.003, 1.010)

 < 0.001

1.005 (1.001, 1.008)

0.011

LDH (U/L)

1.001 (0.997, 1.006)

0.554

1.004 (1.000, 1.009)

0.058

1.004 (1.000, 1.009)

0.075

TBi (mg/dL)

0.344 (0.187, 0.633)

 < 0.001

0.414 (0.226, 0.761)

0.005

0.512 (0.281, 0.932)

0.029

TP (g/L)

1.058 (1.025, 1.092)

 < 0.001

1.051 (1.016, 1.087)

0.004

1.046 (1.012, 1.082)

0.009

ALB (g/L)

0.956 (0.915, 0.998)

0.042

0.947 (0.906, 0.989)

0.015

0.969 (0.926, 1.015)

0.182

GLB (g/L)

1.080 (1.053, 1.107)

 < 0.0001

1.079 (1.049, 1.109)

 < 0.0001

1.064 (1.032, 1.097)

 < 0.0001

ALB/GLB

0.298 (0.182, 0.489)

 < 0.0001

0.294 (0.175, 0.494)

 < 0.0001

0.374 (0.216, 0.649)

 < 0.001

TC (mg/dL)

1.002 (0.999, 1.005)

0.279

1.001 (0.997, 1.004)

0.665

1.002 (0.999, 1.005)

0.222

TG (mg/dL)

1.001 (1.000, 1.002)

0.180

1.001 (1.000, 1.002)

0.194

1.001 (1.000, 1.001)

0.134

HDL-C (mg/dL)

0.986 (0.978, 0.995)

0.001

0.983 (0.974, 0.992)

 < 0.001

0.992 (0.983, 1.001)

0.065

LDL-C (mg/dL)

1.003 (0.998, 1.009)

0.274

1.002 (0.996, 1.008)

0.539

1.003 (0.997, 1.008)

0.296

TC/HDL-C

1.201 (1.081, 1.335)

 < 0.001

1.188 (1.067, 1.322)

0.002

1.146 (1.031, 1.274)

0.012

TG/HDL-C

1.025 (0.994, 1.057)

0.115

1.026 (0.992, 1.061)

0.135

1.022 (0.996, 1.049)

0.096

LDL-C/HDL-C

1.224 (0.972, 1.540)

0.085

1.211 (0.970, 1.513)

0.091

1.184 (0.952, 1.471)

0.127

  1. Crude model: no covariable was adjusted.
  2. Model I: age and gender were adjusted.
  3. Model II: age, gender, race, marital status, education level, family income-to-poverty ratio, and number of cancer types were adjusted.
  4. Abbreviations: ALT, alanine aminotransferase; AST, aspartate aminotransferase; AST/ALT, AST to ALT ratio; ALP, alkaline phosphatase; GGT, gamma glutamyl transferase; LDH, lactate dehydrogenase; TBi, total bilirubin; TP, total protein; ALB, albumin; GLB, globulin; ALB/GLB, ALB to GLB ratio; TC, total cholesterol; TG, triglycerides; HDL-C, high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol; TC/HDL-C, TC to HDL-C ratio; TG/HDL-C, TG to HDL-C ratio; LDL-C/HDL-C, LDL-C to HDL-C ratio.
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