Fig. 3
Early life SOS reduces anxiety-like behavior in males in the OFT. (A) Males exposed to SOS exhibited increased time in the center of the OFT to controls (p = 0.0001). (B) SOS and control males exhibited comparable distance travelled in the OFT (p = 0.80). (C) Female rats exposed to early life SOS and controls exhibited comparable time spent in the center of the OFT (p = 0.12). (D) SOS female and control rats exhibited comparable distance travelled in the OFT (p = 0.84). (E) SOS males travelled greater distances in the center of the OFT compared to controls (p = 0.02). (F) SOS males made more entries into the center of the OFT compared to controls (p = 0.01). (G) SOS and control female rats exhibited comparable distance travelled in the center of the OFT (p = 0.56). (H) SOS and control female rats made similar number of entries into the center of the OFT (p = 0.95). Error bars represent standard error of the mean (SEM). White bars and circles represent controls, orange bars and squares represent SOS males, purple bars and squares represent SOS females. Each dot or square represents 1 animal (n = 6–8 animals per group). * p < 0.05, **** p ≤ 0.0001.
