Fig. 6
Metabolomic changes in serum are observed during COVID-19-associated VAP. (A) Heat map of the significantly changed metabolites when comparing NO VAP group at baseline and follow-up time point. (B) Volcano plot for significant metabolites that pass the threshold of 1.3 -log10 (adjusted p-value). (C) Most changed metabolites from the NO VAP group at baseline and follow-up time points. (D) Heat map of the significant metabolite changes when comparing the baseline and follow-up time points of the VAP group. (E) Volcano plot for significant metabolites that pass the threshold of 1.3 -log10 (adjusted p-value). (F) Most changed metabolites from the VAP group at baseline and follow-up time points. (G) Changes in L-Urobilin and TG normalized values (33:0) in VAP vs. No VAP at time point (1) (H) Changes in normalized values of D-Maltose_D-Lactose in VAP vs. No VAP at time point (2) Student’s t-test was used to calculate the p-value. Asterisks denote the level of significance observed: * = p ≤ 0.05; ** = p ≤ 0.01; *** = p ≤ 0.001.
