Fig. 3 | Scientific Reports

Fig. 3

From: CD38 modulates cytokine secretion by NK cells through the Sirt1/NF-κB pathway, suppressing immune surveillance in colorectal cancer

Fig. 3

The effect of CD38 + NK cells on CD4 + T-cell differentiation. (A) CD38 + NK cells from HCs or CRC patients were pretreated with C-IgG or a CD38 mAb and cocultured with CD4 + T cells in transwell chambers. Representative images showing the effects of CD38 + NK cells from different groups on the differentiation of CD4 + T cells into Tregs. (B) Proportions of Tregs and Th1, Th2, and Th17 cells and the Th17/Treg and Th1/Th2 ratios in the CD4 + T-cell population after coculture. (C) Cytokine levels in the culture supernatants of CD38 + NK cells subjected to different treatments. CD38 + NK (HC): CD38 + NK cells isolated from the blood of healthy controls; CD38 + NK (CRC): CD38 + NK cells isolated from the blood of CRC patients; CRC: colorectal cancer. ns: not statistically significant; *: P < 0.05, **: P < 0.01 and ***: P < 0.001.

Back to article page