Fig. 6 | Scientific Reports

Fig. 6

From: CD38 modulates cytokine secretion by NK cells through the Sirt1/NF-κB pathway, suppressing immune surveillance in colorectal cancer

Fig. 6

Effects of CD38 + NK cells on macrophage polarization. (A) M0 macrophages derived from THP-1 cells were cultured with the culture supernatant of CD38 + NK cells from HCs or CRC patients and pretreated with a CD38 mAb or C-IgG. (B) Representative samples from different groups showing the effect of CD38 + NK cell culture supernatant on macrophage polarization. (C) Proportions of M1 and M2 macrophages after the treatment of M0 macrophages with the culture supernatant of CD38 + NK cells from different groups. CD38 + NK (HC): CD38 + NK cells isolated from the blood of healthy controls; CD38 + NK (CRC): CD38 + NK cells isolated from the blood of CRC patients; HCs: healthy controls; CRC: colorectal cancer; CD38 mAb: anti-CD38 monoclonal antibody; C-IgG: control IgG. ns: not statistically significant; **: P < 0.01 and ***: P < 0.001.

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