Fig. 6 | Scientific Reports

Fig. 6

From: Sirtuin inhibitors reduce intracellular growth of M. tuberculosis in human macrophages via modulation of host cell immunity

Fig. 6

Checkerboard assay to study interactions between primary antibiotics and selected sirtuin inhibitors. hMDMs infected with H37Rv-GFP were treated with (A) RIF or (B) INH using sub-inhibitory concentrations (0.001, 0.01 and 0.1 µg/ml) in combination with a fixed dose (1 µM) of tenovin, suramin, salermide or cambinol. Data assessed with IncuCyte at day 3 is presented in bar graphs (mean and standard error) from n = 4 donors and was analyzed using a two-way RM ANOVA and Tukey´s multiple comparisons test. The dotted lines indicate 50% intracellular Mtb growth. *P < 0.05, **P < 0.01.

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