Fig. 3
From: Development of an efficient NUPR1 inhibitor with anticancer activity
AJO14 and AJO14-derivatives had low affinity for the off-target receptor hERG. (A) Representative graph of the concentration–response curve of E-4031, ZZW-115 and AJO14 binding to hERG, obtained by using a fluorescence polarization assay. Data are presented as mean ± SD, (n = 3). (B) Half-maximal inhibitory concentration (IC50) values on hERG channel inhibition by E-4031, ZZW-115 and AJO14. (C) Representative graph of the concentration–response curve of E-4031 and selected eight AJO14-derivatives binding to hERG, obtained by using a fluorescence polarization assay. Data are presented as mean ± SD, (n = 3).
