Fig. 7
From: Development of an efficient NUPR1 inhibitor with anticancer activity

Calorimetric titration for LZX-2-73 interacting with NUPR1. (A) Thermogram (upper panel) and binding isotherm (lower panel). Non-linear fit according to a model considering a single ligand binding site (continuous line) is shown. Chemical structure of the synthesized LZX-2-73 compound. (B) Interaction parameters of the NUPR1-LZX-2-73 complexes obtained by ITC at 15 °C and pH 7.