Table 1 Interaction parameters of the NUPR1-AJOs complexes obtained by ITC at 15 °C and pH 7.
From: Development of an efficient NUPR1 inhibitor with anticancer activity
Compound | Ka (M−1) | Kd (μM) | ΔH (kcal/mol) | n |
|---|---|---|---|---|
AJO1 | 1.2 × 105 | 8.5 | − 5.2 | 1.3 |
AJO2 | 0.29 × 105 | 35 | − 10.0 | 1.3 |
AJO3 | – | – | – | – |
AJO4 | 0.44 × 105 | 23 | 1.1 | 1.4 |
AJO6 | 0.19 × 105 | 51 | − 2.2 | 1.1 |
AJO7 | 0.11 × 105 | 93 | 5.0 | 1.0 |
AJO8 | 1.2 × 105 | 8.3 | 1.4 | 1.1 |
AJO9 | 1.4 × 105 | 7.1 | 0.6 | 1.3 |
AJO10 | 0.88 × 105 | 11 | − 0.7 | 1.0 |
AJO11 | 0.26 × 105 | 38 | 1.5 | 1.0 |
AJO12 | 2.5 × 105 | 4.0 | 0.9 | 1.1 |
AJO13 | 0.50 × 105 | 20 | 0.7 | 0.9 |
AJO14 | 2.0 × 105 | 4.9 | − 1.2 | 1.2 |
AJO15 | 0.84 × 105 | 12 | 1.3 | 1.3 |
