Table 5 Half-maximal inhibitory concentration (IC50) values for hERG channel inhibition by E-4031 and eight selected AJO14-derivatives.
From: Development of an efficient NUPR1 inhibitor with anticancer activity
Compounds | hERG channel inhibition (IC50 μM) | % Inhibition at 10 μM | % Inhibition at 80 μM |
|---|---|---|---|
E-4031 | 0.05 | 97.2 | 100 |
ED25 | > 80 | 2.8 | 5.4 |
ED28 | > 80 | 14.7 | 22.0 |
ED36 | > 80 | 7.5 | 19.2 |
ED61 | > 80 | 9.2 | 14.8 |
LZX-2-35 | > 80 | 6.9 | 22.6 |
LZX-2-56 | > 80 | 4.7 | 9.5 |
LZX-2-67 | > 80 | 10.0 | 21.6 |
LZX-2-73 | > 80 | 4.4 | 7.1 |
