Table 1 Observed responses in the Box–Behnken design during the optimization of independent variables involved in the preparation of liposomes.
Batches | Independent variables (coded)# | Dependent variables (coded)* | |||
|---|---|---|---|---|---|
X1 | X2 | X3 | Y1 | Y2 | |
LP-ASPM-F1 | 0 | -1 | + 1 | 112.7 ± 2.9 | 55.75 ± 3.00 |
LP-ASPM-F2 | + 1 | 0 | + 1 | 118.6 ± 1.8 | 47.90 ± 2.6 |
LP-ASPM-F3 | 0 | 0 | 0 | 124.4 ± 0.4 | 48.07 ± 0.1 |
LP-ASPM-F4 | 0 | -1 | -1 | 132.3 ± 1.7 | 60.55 ± 1.6 |
LP-ASPM-F5 | -1 | 0 | -1 | 131.3 ± 0.8 | 59.23 ± 1.2 |
LP-ASPM-F6 | 0 | + 1 | + 1 | 116.9 ± 3.2 | 41.11 ± 1.1 |
LP-ASPM-F7 | -1 | + 1 | 0 | 124.9 ± 2.1 | 52.01 ± 2.8 |
LP-ASPM-F8 | -1 | -1 | 0 | 131.3 ± 1.3 | 59.59 ± 1.5 |
LP-ASPM-F9 | -1 | 0 | + 1 | 119.6 ± 1.5 | 57.44 ± 0.5 |
LP-ASPM-F10 | 0 | + 1 | -1 | 112.5 ± 1.9 | 59.79 ± 2.2 |
LP-ASPMS-F11 | + 1 | 0 | -1 | 113.3 ± 2.6 | 49.44 ± 1.3 |
LP-ASPM-F12 | 0 | 0 | 0 | 124 ± 0.3 | 48.96 ± 1.0 |
LP-ASPM-F13 | + 1 | + 1 | 0 | 118.4 ± 2.2 | 43.04 ± 0.9 |
LP-ASPM-F14 | + 1 | -1 | 0 | 122.4 ± 2.5 | 46.20 ± 3.1 |
LP-ASPM-F15 | 0 | 0 | 0 | 124.3 ± 0.4 | 48.43 ± 0.5 |
