Table 2 Demographics and clinical characteristics.

From: Intraventricular antibiotics for severe central nervous system infections: a case series

 

Overall

CA-CNSI

HAVM

p-Value

Number

27

13

14

 

Sex (n = female, (%))

14 (51.9)

7 (53.8)

7 (50.0)

1.000

Age (as years, mean (SD))

54.1 (15.6)

47.9 (16.2)

59.9 (13.1)

0.045

CCI (median [IQR])

2 [0.5 – 4]

1 [0 – 5]

1.5 [1 – 4]

0.921

SAPS II (mean (SD))

43.6 (15.0)

41.5 (16.4)

45.9 (13.7)

0.470

GCS at hospital admission (median [IQR])

9 [5.5 – 13]

10 [7 – 12]

8 [4– 13.75]

0.507

GCS at NCCU admission (median [IQR])

3 [3 – 4]

3 [3 – 4]

3 [3 – 4]

0.705

Seizures

   

0.822

None (n (%))

14 (51.9)

6 (46.2)

8 (57.1)

 

Focal (n (%))

6 (22.2)

3 (23.1)

3 (21.4)

 

Generalised (n (%))

7 (25.9)

4 (30.8)

3 (21.4)

 

Status Epilepticus

   

0.564

None (n (%))

22 (81.5)

10 (76.9)

12 (85.7)

 

Focal (n (%))

1 (3.7)

1 (7.7)

0 (0)

 

Generalised (n (%))

4 (14.8)

2 (15.4)

2 (14.3)

 
  1. Data in brackets represent percentages. Data in square brackets represent IQR (interquartile ranges). CA-CNSI (community-acquired central nervous system infection); CCI (Charlson Comorbidity Index); GCS (Glasgow Coma Scale); HAVM (healthcare-associated ventriculitis and meningitis); NCCU (intensive care unit); SAPS II (Simplified Acute Physiology Score II). SD (standard deviation). Comparisons among patients with CA-CNSI and those with HAVM were performed.