Table 4 Outcomes.

From: Intraventricular antibiotics for severe central nervous system infections: a case series

 

Overall

CA-CNSI

HAVM

p-Value

NCCU-LOS (days, median [IQR])

25 [16 – 30]

22 [6 – 30]

25.5 [19.25 – 30]

0.369

H-LOS (days, median [IQR])

29 [23– 60.5]

26 [23 – 48]

40 [27.25 – 61.75]

0.331

mRS at discharge

   

0.525

No symptoms (n (%))

0 (0.0)

0 (0.0)

0 (0.0)

 

No significant disability (n (%))

1 (3.7)

1 (7.7)

0 (0.0)

 

Slight disability (n (%))

4 (14.8)

3 (23.1)

1 (7.1)

 

Moderate disability (n (%))

4 (14.8)

2 (15.4)

2 (14.3)

 

Moderate-severe disability (n (%))

4 (14.8)

1 (7.7)

3 (21.4)

 

Severe disability (n (%))

9 (33.3)

3 (23.1)

6 (42.9)

 

Death (n (%))

5 (18.5)

3 (23.1)

2 (14.3)

 

mRS at 6 months

   

0.729

No symptoms (n (%))

3 (16.7)

2 (20.0)

1 (12.5)

 

No significant disability (n (%))

1 (5.6)

1 (10.0)

0 (0.0)

 

Slight disability (n (%))

4 (22.2)

3 (30.0)

1 (12.5)

 

Moderate disability (n (%))

4 (22.2)

2 (20.0)

2 (25.0)

 

Moderate-severe disability (n (%))

3 (16.7)

1 (10.0)

2 (25.0)

 

Severe disability (n (%))

3 (16.7)

1 (10.0)

2 (25.0)

 

Death (n (%))

0 (0.0)

0 (0.00)

0 (0.0)

 

mRS at 12 months

   

0.657

No symptoms (n (%))

3 (18.8)

2 (22.2)

1 (14.3)

 

No significant disability (n (%))

2 (12.5)

2 (22.2)

0 (0.0)

 

Slight disability (n (%))

2 (12.5)

1 (11.1)

1 (14.3)

 

Moderate disability (n (%))

2 (12.5)

1 (11.1)

1 (14.3)

 

Moderate-severe disability (n (%))

4 (25.0)

1 (11.1)

3 (42.9)

 

Severe disability (n (%))

1 (6.2)

1 (11.1)

0 (0.0)

 

Death (n (%))

2 (12.5)

1 (11.1)

1 (14.3)

 

mRS at 24 months

   

0.119

No symptoms (n (%))

2 (20.0)

2 (40.0)

0 (0.0)

 

No significant disability (n (%))

2 (20.0)

2 (40.0)

0 (0.0)

 

Slight disability (n (%))

0 (0.0)

0 (0.0)

0 (0.0)

 

Moderate disability (n (%))

3 (30.0)

1 (20.0)

2 (40.0)

 

Moderate-severe disability (n (%))

2 (20.0)

0 (0.0)

2 (40.0)

 

Severe disability (n (%))

0 (0.0)

0 (0.0)

0 (0.0)

 

Death (n (%))

1 (10.0)

0 (0.0)

1 (20.0)

 
  1. CA-CNSI, community-acquired central nervous system infection; HAVM (healthcare-associated ventriculitis and meningitis); H-LOS (hospital length of stay); NCCU-LOS (neurocritical care unit length of stay); mRS (modified Rankin Scale). Comparisons among patients with CA-CNSI and those with HAVM were performed.
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