Fig. 4 | Scientific Reports

Fig. 4

From: Sex disparities in the association between rare earth elements exposure and genetic mutation frequencies in lung cancer patients

Fig. 4The alternative text for this image may have been generated using AI.

(A) Mutational landscape showing the mutation types and rates of most frequently mutated genes in the overall cohort. (B) Mutational landscape showing the mutation types and rates of most frequently mutated genes in male patients (upper image) and female patients (lower image). Correlation of the variant allele frequencies (VAFs) of highly mutated genes and La and Ce in male patients (C) and female patients (D). The x-axis and y-axis represent the correlation coefficient (rho) and log-transformed P value. The absolute contributions of the SBS and ID mutational signatures for the mutation spectrum of each patient are displayed in male patients (E) and female patients (F), along with the corresponding levels of REEs (sorted in descending order of La). (G) The correlation of the three ID signatures (ID1, ID2, and ID12) and La concentration in male (left) and female (right) patients.

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