Fig. 1

SA induces ferroptosis in mouse livers. Mice were intraperitoneally (i.p.) injected with vehicle, SA (3.6, 7.2 mg/kg), Fer-1 (5 mg/kg/d) or SA (3.6 mg/kg/d) + Fer-1 (5 mg/kg/d). After 10 d, the relative liver weight index was measured (A). Serum AST and ALT in each group were measured (B). Images of H&E staining (HE) of the liver Sect. (200 × magnification): ① edema of hepatocytes, ② compensatory hypertrophy of liver (C). Hepatic MDA (D), GSH (E) and Fe²⁺ content (F) were assessed. Values are expressed as the mean ± SD (n = 6). *p < 0.05, **p < 0.01, ***p < 0.001 vs. control group.