Table 2 4-bin scoring of androgen receptor (AR) positivity in young (2 months, n = 8) and aged (24 months, n = 9) prostates. Values are percentages (%) of AR-negative (0) and mild- (1), moderate- (2), and strong- (3) AR-positive cells. Values are presented as mean (SD). Bold values have statistical significance in young vs. aged by Student’s t-test (equal variances)/Welch’s t-test (unequal variances). *p < 0.05, **p < 0.01, ***p < 0.001.
From: Prostatic androgen receptor signaling shows an age-related and lobe-specific alteration in mice
Prostate lobe | Anterior prostate | Ventral prostate | Dorsal-lateral prostate | |||
|---|---|---|---|---|---|---|
Age | 2 months | 24 months | 2 months | 24 months | 2 months | 24 months |
A. Total (%) | ||||||
0 | 16.12 (7.19) | 21.02 (10.39) | 9.35 (5.02) | 15.15 (10.27) | 19.17 (9.59) | 23.74 (5.95) |
1 | 38.36 (10.91) | 43.16 (9.98) | 21.42 (8.53)** | 39.55 (13.09)** | 36.04 (10.54) | 36.72 (6.07) |
2 | 41.77 (14.98) | 34.39 (16.90) | 41.55 (7.75)* | 32.57 (9.51)* | 35.24 (10.72) | 31.37 (8.53) |
3 | 3.75 (2.27)* | 1.43 (1.56)* | 27.69 (14.21)* | 12.73 (12.73)* | 9.55 (9.10) | 8.17 (8.26) |
B. Epithelium (%) | ||||||
0 | 11.41 (5.43) | 17.42 (13.64) | 8.19 (2.76)* | 16.79 (8.62)* | 15.25 (7.50) | 16.78 (6.92) |
1 | 41.20 (12.38) | 43.45 (11.55) | 18.07 (8.92)*** | 40.66 (14.47)*** | 35.84 (11.32) | 31.99 (8.95) |
2 | 44.51 (15.06) | 37.78 (19.87) | 44.07 (8.20)* | 32.63 (11.95)* | 39.35 (8.69) | 39.74 (8.01) |
3 | 2.87 (2.10) | 1.34 (1.65) | 29.67 (15.52)** | 9.92 (11.48)** | 9.56 (9.84) | 11.50 (10.48) |
C. Stroma (%) | ||||||
0 | 13.53 (5.09)** | 33.15 (14.06)** | 39.03 (11.88) | 57.82 (28.17) | 23.61 (5.88) | 29.09 (13.62) |
1 | 27.06 (10.73)* | 38.15 (5.04)* | 49.68 (12.60) | 32.71 (19.29) | 27.83 (6.36) | 29.67 (9.31) |
2 | 41.65 (8.92)** | 25.07 (13.51)** | 12.46 (6.13) | 8.20 (9.93) | 36.26 (5.23) | 33.49 (16.46) |
3 | 17.76 (9.12)*** | 3.64 (3.17)*** | 0.84 (1.15) | 1.27 (2.27) | 12.30 (9.39) | 8.75 (6.16) |
