Table 2 The MIC90 values and FICI parameters resulting from the the checkerboard analysis of drug interaction between L-penicillamine (L-PEN) and L-4-acetamido-2-aminobutanoic acid (AcDAB), DL-2-allyglycine (DL-ALG) or DL-glufosinate (DL-GLUF) against C. Glabrata and C. Albicans in YNB minimal medium containing sodium glutamate (SG) as a nitrogen source. FICI—Fractional Inhibitory Concentration Index. *Value used for FICI calculations, although MIC90 was not actually reached.
From: Targeting Candida albicans O-acetyl-L-homoserine sulfhydrylase (Met15p) in antifungal treatment
Inhibitor | MIC90 [µg∙mL−1] | FICI | Effect | |
|---|---|---|---|---|
Alone | In combination | |||
C. glabrata ATCC 90030 | ||||
AcDAB | 2048* | 128 | 0.313 | Synergy |
L-PEN | 512 | 128 | ||
DL-ALG | 8 | 0.5 | 0.0938 | Synergy |
L-PEN | 512 | 16 | ||
DL-GLUF | 128 | 64 | 1.00 | Indifferent |
L-PEN | 512 | 256 | ||
C. albicans ATCC 10231 | ||||
AcDAB | 1024 | 128 | 0.375 | Synergy |
L-PEN | 1024 | 256 | ||
DL-ALG | 64 | 16 | 0.50 | Synergy |
L-PEN | 1024 | 256 | ||
DL-GLUF | 256 | 512 | 1.50 | Indifferent |
L-PEN | 1024 | 1024 | ||
