Table 1 Description of selected features used to capture the exposome.

Socio-demographic^40,41, physical measures^42,43, behavioural factors^40,44, and population structure^7,45

Age at recruitment, year of birth, sex, Townsend deprivation index, education status, body mass index, hip circumference, sitting height, standing height, waist circumference, weight, alcohol use, smoking and ancestry principal components (PCs)

Dietary intake^46,47,48

Bread intake, cereal intake, coffee intake, cooked vegetable intake, dried fruit intake, fresh fruit intake, salad/ raw vegetable intake, tea intake, water intake, beef intake, cheese intake, lamb/mutton intake, oily fish intake, pork intake and poultry intake

Medical conditions^49,50,51

Cancer diagnosed by doctor, diabetes diagnosed by doctor, blood clot, deep vein thrombosis (DVT), bronchitis, emphysema, asthma, rhinitis, eczema, allergy diagnosed by doctor, diastolic blood pressure automated reading, pulse rate automated reading, and systolic blood pressure automated reading