Fig. 6 | Scientific Reports

Fig. 6

From: Publisher Correction: Novel laser model of optic nerve transection provides valuable insights about the dynamics of optic nerve regeneration

Fig. 6The alternative text for this image may have been generated using AI.

Cutting the optic nerve with a laser has a slight effect on gene expression in the retina at 3 days PL. (A) Retinas from experimental and control eyes were collected for RNA isolation three days after optic nerve transection. (B) RNA-seq data indicate that counts per million (CPM) distributions for control (Ret_C) and experimental (Ret_L) retinas do not differ significantly 3 days after injury. (C) To demonstrate the correlation (Corr) between gene expression in Ret_C vs. Ret_L retinas, scatter plots were utilized (D) The principal component analysis (PCA) shows a slight difference between control and experimental retinas. (E) The heatmap shows genes whose expression differs greatly in Ret_C vs. Ret_L retinas. (F) The volcano plot shows that the number of genes whose expression was statistically significantly (FDR < 0.1) decreased or increased |lfc| >1 in experimental and control retinas was small. (G) Subtle changes in gene expression are reflected in the low representation of significant biological processes or cellular components that may play a role in retinas with injured optic nerves.

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