Fig. 7 | Scientific Reports

Fig. 7

From: Publisher Correction: Novel laser model of optic nerve transection provides valuable insights about the dynamics of optic nerve regeneration

Fig. 7The alternative text for this image may have been generated using AI.

Optic nerve transection results in significant changes in gene expression at the lesion site at 3 days PL. (A) Three days after injury, optic nerves were collected for RNA extraction and RNA-seq library preparation. (B) RNA-seq library analysis indicates that CPM distributions do not differ between control (ON_C) and injured (ON_L) optic nerves. (C-E) Scatter plot matrix (C), PCA (D), and volcano plot (E) show significant differences between control and injured optic nerves at the gene expression level. F) Top significantly up- and down-regulated genes are shown in the heatmap. G) The gene ontology (GO) enrichment analysis shows that many genes whose expression is increased in injured optic nerves are involved in the cell cycle, while genes whose expression is decreased are involved in synaptogenesis.

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