Table 1 Baseline characteristics of the four groups: (A) normal levels of PTH and low IGFBP-1; (B) normal levels of PTH and high IGFBP-1; (C) elevated levels of PTH and low IGFBP-1; (D) elevated levels of PTH and high IGFBP-1.

From: Levels of parathyroid hormone and IGF binding protein 1 and associations with mortality and hip fractures in older women

 

All participants

(n = 338)

Normal PTH < 65ng/L

(n = 250)

Elevated PTH ≥ 65ng/L

(n = 88)

p-value

Low IGFBP-1n = 124

High IGFBP-1n = 126

Low IGFBP-1n = 43

High IGFBP-1n = 45

PTHa ng/L

Md (min-max)

52.9 (13.7- 171.8)

48 (21–65)

45 (14–65)

76 (66–157)

83 (66–172)

 

IGFBP-1b µg/L

29 (5-169)

19 (5–28)

43 (29–104)

20 (8–28)

43 (29–169)

Age (y), Md (IQR)

72.4 (71.1–73.8)

72.2 (71.1–73.4)

72.2 (71.1–73.7)

73.0 (71.2–74.2)

73.2 (71.8–76.1)

0.027o*

BMIc kg/m2, mean (SD)

27 (4)

28 (4)

25 (3)

30 (5)

27 (5)

< 0.001o*

BMDd at femoral neck, mean (SD)

0.65 (0.10)k

0.68l (0.10)

0.62l (0.10)

0.67l (0.08)

0.63 (0.08)

< 0.001p*

Diseases n (%)

Earlier/present cancer

44 (13)

13 (10)

20 (16)

3 (7)

8 (18)

0.281q

Asthma/COPDe

35 (10)

13 (10)

11 (9)

8 (19)

3 (7)

0.288q

CVDf

126 (37)

39 (31)

35 (28)

25 (58)

27 (60)

< 0.001r*

Diabetes (%)

28 (8)

9 (7)

10 (8)

7 (16)

2 (4)

0.234q

Risk factors n (%)

Cigarette smoking

53 (16)

21 (17)

22 (17)

5 (12)

5 (11)

0.638r

Outdoors ≥ 30 min/day

286 (85)l

106 (85)

112 (89)

36 (84)

32 (73)l

0.082r

Medications n (%)

Loop diuretics

28 (8)

7 (6)

4 (3)

6 (14)

11 (24)

< 0.001q*

Bisphosphonates

8 (2)

3 (2)

5 (4)

0 (0)

0 (0)

0.474q

Calcium + VitD3

26 (8)

13 (10)

10 (8)

1 (2)

2 (4)

0.316q

Insulin

6 (2)

2 (2)

3 (2)

0 (0)

1 (2)

0.941q

Oral Anti diabetics

11 (3)

5 (4)

5 (4)

1 (2)

0 (0)

0.694q

Blood levels mean

Calcium mmol/Lg (SD)

1.2 (0.04)l

1.2 (0.04)

1.2 (0.03)l

1.2 (0.06)

1.2 (0.05)

0.505o

Hypercalcemia n (%)h

11 (3)l

3 (2)

0 (0)l

5 (12)

3 (7)

0.001q*

Creatinine µmol/Li (SD)

85.3 (10.6)m

84.4 (9.9) l

83.8 (9.0) l

85.0 (10.4)

92.4 (13.7)

0.001o*

Albumin g/Li (SD)

39.7 (2.9)m

40.3 (2.9) m

39.4 (3.0)

39.1 (2.4)

39.2 (2.6)

0.020p*

25-OH vitamin D, nmol/L (IQR)

92 (70 —111)

96 (77—110)m

93 (72—115)n

76 (61—101)

79 (70—102)

0.0045o

GFR (SD)j

58.1 (12.0)m

61.2 (10.8) l

55.0 (11.0) l

64.0 (13.0)

52.5 (12.3)

< 0.001p*

GFR < 60j yes n (%)

195 (58)

58 (47)

86 (68)

17 (40)

34 (76)

< 0.001r

  1. a PTH = parathyroid hormone, b IGFBP-1 = Insulin-like growth factor binding protein 1, c BMI = Body mass index, d BMD = bone mineral density, g/cm2, e COPD = chronic obstructive pulmonary disease, f CVD = cardiovascular disease (defined as ICD10 codes I00–I99), g ionized calcium in plasma, h >1.29 mmol/L, i serum, j GFR = glomerular filtration rate (Cockcroft-Gault), (mL/min/1.73 m2), k six missing values, l one missing value, m two missing values, n three missing values, o Kruskal–Wallis, p One-way ANOVA q Fisher’s exact test.
  2. r Chi2 test, *P-value less than 0.05.
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