Fig. 2 | Scientific Reports

Fig. 2

From: A multiparametric screen uncovers FDA-approved small molecules that potentiate the nuclear mechano-dysfunctions in ATR-defective cells

Fig. 2

Results of the primary high content screening. Distribution of the z-scores for (a) the percentage of nuclei with invaginations, (b) Lamina Fragmentation and (c) roundness parameters. 18 Assay Plates are represented in the figure. Each compound was tested at three doses (10–1–0.1 μM). Each single dose is distributed in plate A, B and C respectively. Z-scores are calculated for each sample (light gray dots) after normalization on shATR HeLa treated with DMSO (blue dots). shCTRL HeLa cells treated with DMSO are depicted in red. Selected hits (Active-UP/DOWN) are highlighted with green stars according to cut-off value.

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