Table 2 IC50 values [μM] of DCF, CCF, o1, m1, p 1, 2, and 3 on cancer cell lines MC38, HCT116, and HT29.

From: Re-design and evaluation of diclofenac-based carborane-substituted prodrugs and their anti-cancer potential

#

IC50 [μM] (n = 3)

MC38

HCT116

HT29

MTT

CV

MTT

CV

MTT

CV

DCF

> 100

> 100

> 100

> 100

> 100

> 100

CCF

32.6 ± 2.7

75.1 ± 3.8

46.7 ± 2.4

73.5 ± 3.9

77.7 ± 5.5

74.4 ± 4.8

o1

> 100

> 100

> 100

> 100

> 100

> 100

m1

> 100

> 100

> 100

> 100

> 100

> 100

p1

> 100

> 100

> 100

> 100

> 100

> 100

2

> 100

> 100

> 100

> 100

> 100

> 100

3

7.9 ± 0.2

9.5 ± 0.4

6.9 ± 1.5

11.5 ± 1.0

17.0 ± 1.6

17.6 ± 0.3

  1. Data are presented as mean±SD of three independent experiments obtained by MTT and CV tests.