Fig. 6 | Scientific Reports

Fig. 6

From: Using parenclitic networks on phaeochromocytoma and paraganglioma tumours provides novel insights on global DNA methylation

Fig. 6The alternative text for this image may have been generated using AI.

Venn diagram presenting the overlap in the genes associated with differentially methylated loci and regions identified by dmpFinder and bumphunter respectively and candidates identified using parenclitic networks. All three methods have been applied to identify differences between aggressive and non-aggressive PPGL. There is no overlap between dmpFinder and the other methods. There is a small overlap between bumphunter and Parenclitic networks including KIAA0040, ADAMTS12, ELOVL7, OCA2, KIF26B, VGLL4, HLA-H, HIF3A, GDAP2. Bumphunter presents greater similarity to the parenclitic networks approach presented here compared to dmpFinder. This is because dmpFinder investigates differences at the level of individual CG loci, whereas bumphunter is looking at broader regions. Parenclitic networks broaden the area of interest further by taking into account interaction between loci regardless of genomic distance. Parenclitic networks, in contrast to dmpFinder and bumphunter, identify CG loci that play a key role in the DNA methylation alterations in multiple regions of the genome instead of isolated changes.

Back to article page