Fig. 1
Clinical anesthetics and analgesics inhibit cancer progression and alleviate resistance to EGFR-TKIs. (A) Effects of 16 analgesic anesthetic injections on the proliferation of H1975, A549, H1299, and HCC827 cells. (B, C, D and E) H1975, A549, H1299, and HCC827 cells were treated with increasing doses of butorphanol tartrate injection. (F, G, H, I and J) Effects of different concentrations of butorphanol tartrate injection on colony formation in the NSCLC cell lines H1975, A549, H1299, and HCC827. The area of colony formation was measured using ImageJ software. (K) Effects of butorphanol tartrate, a component of butorphanol tartrate injection, on H1975 cell proliferation. (L) Effects of benzethonium chloride, a component of butorphanol tartrate injection, on H1975 cell proliferation. The results are expressed as the mean ± standard deviation of three separate and distinct experiments (n = 3). (*P < 0.05, **P < 0.01, ***P < 0.001 compared with DMSO).
