Table 4 Mediation analysis for the associations between TyG index and the risk of stroke in patients with carotid artery stenosis.

From: Insulin resistance, vulnerable plaque and stroke risk in patients with carotid artery stenosis

Exposures

Direct effect

Indirect effect

Proportion mediated (%)

Coefficient (95% CI)

P value

Coefficient (95% CI)

P value

Unadjusted

0.0031 (0.0014, 0.0060)

< 0.001

0.0007 (0.0003, 0.0013)

< 0.001

18.3

Model I

0.0027 (0.0011, 0.0051)

< 0.001

0.0005 (0.0002, 0.0009)

< 0.001

15.8

Model II

0.0025 (0.0008, 0.0049)

0.002

0.0004 (0.0001,0.0007)

0.003

13.9

Model III

0.0023 (0.0007, 0.0045)

0.028

0.0003 (0.0001, 0.005)

0.017

11.6

  1. Model I was adjusted for age, smoke and hypertension. Model II was adjusted for age, BMI, HDL-C and homocysteine. Model III was adjusted for age, BMI, HDL-C, smoke, homocysteine and hypertension. CI confidence interval.
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