Fig. 1 | Scientific Reports

Fig. 1

From: CpG hypomethylation at proximal promoter and 5’UTR along with IL6 signaling loop associates with MYD88 upregulation in epithelial ovarian cancer

Fig. 1

Bioinformatics of CpG methylation in theMYD88 promoter and MYD88 mRNA in ovarian cancer. (a) MYD88 promoter CpG methylation median value in 10 normal individuals is evidently higher than that in 24 EOC cases from database of DiseaseMeth V3.0 (P < 0.01). (b) Mean TPM value of MYD88 mRNA in 88 normal individuals is clearly lower than in 147 EOC cases from databases of GTEx and TCGA, respectively (P < 0.001). (c) The analyzed 27 CpG sites, 1 GC box (gggcgg), SP1 binding motif (GGGCGG) and IRF1 binding motif (CTTCGGAAAGCGAAAG) in nucleotide sequence (-244 ~ + 167 bp) of MYD88 proximal promoter /5’UTR. **, P < 0.01; ***, P < 0.001.

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