Fig. 5 | Scientific Reports

Fig. 5

From: CpG hypomethylation at proximal promoter and 5’UTR along with IL6 signaling loop associates with MYD88 upregulation in epithelial ovarian cancer

Fig. 5

Expression of related markers in EOC and normal ovarian tissues and prognostic role in patients. (a) Median frequency of CpG methylation of MYD88 proximal promoter/5’UTR (-244 ~ + 167 bp) in 28 normal ovarian tissue samples was significantly higher than that in 75 EOC tissue samples. (b) MYD88 mRNA expression and median frequency of CpG methylation in the MYD88 proximal promoter /5’UTR was significantly negatively correlated in 75 EOC tissue samples (R2 = 0.438, P < 0.001). (c) MYD88 mRNA expression was positively associated with IL-6 mRNA expression in 75 EOC tissue samples (R2 = 0.522, P < 0.001). (d,e) Mapping of methylated CpG sites in the MYD88 proximal promoter /5’UTR in 38 EOC cases with lowly expressed MYD88 and in 37 EOC cases with highly expressed MYD88, respectively. (f–k) The prognostic role of MYD88 methylation, MYD88 mRNA and IL-6 mRNA for PFS and OS in 75 patients with EOC.

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