Fig. 8
Drug sensitivity analysis and prediction of immunotherapy effectiveness. (A) List of drugs related to SLCO4A1-AS1. The horizontal axis represents the names of the drugs, while the vertical axis indicates the correlation coefficients between drug sensitivity and SLCO4A1-AS1 expression levels. The colors of the bars represent the statistical P value. (B) Targeted pathways of drug resistance. (C) Targeting pathways for sensitive drugs. The horizontal axis represents the names of the drugs, while the vertical axis indicates the signaling pathways targeted by these drugs. The bar graph on the right side of the plot displays the number of drugs targeting each specific pathway. The colors of the points represent the correlation coefficients between drug sensitivity and SLCO4A1-AS1 expression levels. (D) Distribution of clinical characteristics of patients in the GSE121810 database. (E) GBM patients with high SLCO4A1-AS1 expression had a poorer prognosis after receiving immunotherapy. (F) ROC curves showed that SLCO4A1-AS1 had high accuracy in predicting OS in GBM patients receiving immunotherapy. (G) Higher TIDE scoring in the high expression group. (H) Patients with high TIDE score have a poorer prognosis. (I) Immunotherapy was more effective in the low expression group. (J) ROC curves for predicting the effectiveness of immunotherapy. (K–N) Lower expression group has higher IPS and may have better immunotherapy responsiveness. Significant statistical differences between the two groups were assessed using the Mann–Whitney test. NS, not statistically significant; * P < 0.05; ** P < 0.01; *** P < 0.001.
