Fig.5
(A). kM-RIIIJ increases the influx of persistent sodium currents for the duration of ramp. Application of 100 nM kM-RIIIJ (red trace) significantly increased influx of persistent sodium currents for the duration of the ramp protocol by 14% in the range of -20 mV to + 5 mV compared to control (black trace). The effects were abolished in the presence of 1 μM TTX (blue and green trace). (B). 100 nM kM-RIIIJ increased the influx of charge density from -33.38 C/m2 (control black trace) to -60.16 C/m2 (red trace). n = 15 proprioceptor DRG neurons. *p < 0.05, ** p < 0.01, *** p < 0.001 determined by Wilcoxon matched-pairs signed rank test.
