Fig. 5
From: Omics-based analysis of mitochondrial dysfunction and BBB integrity in post-COVID-19 sequelae
ACE2 receptor-mediated SARS-CoV-2 entry inside the human body. The expression of Angiotensin-converting enzyme 2 (ACE2) by brain region and cells facilitates the entry of viral spike protein from the peripheral system to the central nervous system. The uptake of virus genome content by the host cell results in targeted degeneration of mitochondria i.e. the powerhouse of the cell. This results in the collapse of major metabolisms of cells ultimately, causing cell death.
