Table 2 Diagnostic characteristics of the individual sleep biomarkers used for NDD profiling.
Sleep Biomarker | Disease Category(s) | Unaffected Category(s) | Abnormal Cutoff | ROC-AUC | Sensitivity | Specificity |
|---|---|---|---|---|---|---|
Lewy Body Dementia | ||||||
REM time | LBD | AD, PD, MCI, iRBD, CG | ≤ 30 min | 0.78 | 0.63 | 0.93 |
Spindle duration | ≤ 1 min | 0.74 | 0.84 | 0.63 | ||
Atypical N3 | ≥ 4% sleep time | 0.66 | 0.42 | 0.89 | ||
Synucleinopathy | ||||||
Non-REM hypertonia | LBD, PD, iRBD | AD, MCI, CG | ≥ 5% sleep time | 0.74 | 0.70 | 0.79 |
Autonomic activation | < 10 events/h | 0.65 | 0.54 | 0.75 | ||
Dementias & cognitive Impairment | ||||||
NREM relative theta | LBD, AD, MCI | PD, iRBD, CG | ≥ 18.5% | 0.71 | 0.68 | 0.73 |
NREM theta/alpha | ≥ 1.40 | 0.63 | 0.52 | 0.74 | ||
NDD Condition | ||||||
Sleep efficiency | LBD, AD, MCI, PD, iRBD | CG | ≤ 80% | 0.65 | 0.41 | 0.89 |
Supine sleep | ≥ 120 min | 0.61 | 0.63 | 0.59 | ||
