Fig. 3

ROC curve for patients with HLH and AOSD only (CCS patients excluded). AUC for CRP alone is 0.845 with a sensitivity of 90.9% and specificity of 81.8% for CRP < 130 mg/L (red). AUC for HScore in this subset analysis was 0.852 with a sensitivity of 79.5% and specificity of 81.8% for HScore > 148 (blue). When CRP is combined with HScore, AUC improves to 0.959 with sensitivity of 86.4% and specificity of > 99% for the combined ROC curve (green).