Fig. 3

Validation of the in silico model against current treatment strategies. (1) Corticosteroid applied at week 3, i.e., after the disease onset¹⁵, (b) corticosteroid applied at day 10, i.e., before the disease onset³⁷, and (c) anti-IL-13 use at week 3, i.e., after the disease onset, in a mouse model¹⁵. All data points (black circles with SEM error bars) and simulation dynamics (solid green lines) are plotted as a fold change in treatment application vs placebo with HDM present from day 3 of life. Grey shaded regions indicate HDM present, dark green shaded regions indicate treatment interventions before disease onset, light green shaded regions indicate therapeutic treatment use after disease onset.