Fig. 4

In silico long-term outcomes of HDM exposures of varied initial times and durations. Results for (a) the validated in silico model of the nominal virtual mouse and (b) the in silico model with modified parameters (an alternative virtual mouse, Figure S2). (Top) Switch plots that summarise the simulation results of long-term disease states as a result of HDM exposure for different durations starting at different timings. (Middle and bottom) Example dynamics as a result of the in silico model simulation for three representative scenarios of HDM exposure (1) at week 1 for 1 (dashed lines), 3 (dotted lines), and 5 (solid lines) weeks and (2) at week 4 for 0.5 (dashed lines), 1.3 (dotted lines), and 2 (solid lines) weeks. The black dots in the top rows of switch plots indicate the three representative scenarios in (1) and the grey dots in the top rows of switch plots indicate the three representative scenarios in (2).