Table 1 Table of parameters in in silico model (1).
From: Mechanistic modelling of allergen-induced airways disease in early life
Parameter | Description | Dimension | Value |
|---|---|---|---|
δH | Rate of epithelial barrier damage caused by protease activity of HDM | Time−1 | 0.0605 |
αH | Proportion of epithelial barrier damage upregulated by a damaged/leaky barrier | – | 9.4898 |
δD | Rate of epithelial barrier damaged caused by eosinophilic inflammation | Time−1 | 0.0745 |
κR | Rate of remodelling | – | 0.1260 |
κB | Rate of epithelial barrier repair | Time−1 | 0.1069 |
κE | Rate of eosinophil recruitment | Time−1 | 9.1306 |
αI | Proportion of eosinophil recruitment upregulated by allergic sensitisation | – | 0.5690 |
αN | Proportion of Th1 inhibition on Th2 | – | 166.2375 |
κS | Rate of additional eosinophilic inflammation due to sensitisation | Time−1 | 0.0361 |
δE | Rate of eosinophil natural degradation (net loss) | Time−1 | 2.4665 |
κN | Rate of neutrophil recruitment | Time−1 | 0.0663 |
αE | Proportion of Th2 inhibition on Th1 | – | 0.0065 |
δN | Rate of neutrophil natural degradation (net loss) | Time−1 | 0.7909 |
κA | Rate of increase in airway resistance caused by basal sources such as mucus and airway smooth muscle | Time−1 | 0.1575 |
κD | Rate of increase in airway resistance due to excessive epithelial barrier damage as epithelial cells are replaced by stiffer extracellular matrix during a dysregulated repair process | Time−1 | 0.1925 |
κF | Rate of increase in airway resistance due to eosinophilic inflammation, including mucus accumulation, by reducing airflow | Time−1 | 1.2582 |
κG | Rate of increase in airway resistance due to neutrophilic inflammation, including mucus accumulation, by reducing airflow | Time−1 | 0.0065 |
δA | Rate of resolution in airway resistance | Time−1 | 2.5245 |
β | Amplitude of Th2 skewing | – | 7.4060 |
γ | Amplitude of lung growth | – | 4.9287 |
λ | Rate of immune maturation | Time−1 | 0.6982 |
μ | Rate of lung-growth | Time−1 | 0.7229 |
Dthres | Threshold damage for remodelling to occur | – | 0.6648 |
Ethres | Threshold type 2 cells for sensitisation to occur | – | 0.3077 |
Won | Week HDM challenge begins | Time | 3/7, 7 |
Woff | Week HDM challenge is removed | Time | 3, 6, 8, 10, 12 |
