Table 4 Univariate logistic regression and binary logistic regression performance in the differentiation of HGG and SBM.

From: Bi-exponential diffusion-weighted imaging for differentiating high-grade gliomas from solitary brain metastases: a VOI-based histogram analysis

 

AUC

(95% CI)

Sensitivity

(95% CI)

Specificity

(95% CI)

Accuracy

(TN + TP)/(N + P)

PPV

(TP/P)

NPV

(TN/N)

Threshold

ETA

 Dfast_skewness

0.67

(0.52,0.83)

0.58

(0.38.0.77)

0.77

(0.61,0.90)

0.68

(39/57)

0.68

(15/22)

0.69

(24/35)

0.87

 Dslow_entropy

0.71

(0.58,0.85)

0.88

(0.77,1.00)

0.55

(0.39,0.71)

0.70

(40/57)

0.62

(23/37)

0.85

(17/20)

3.85

 frac_mean

0.71

(0.57,0.85)

0.58

(0.38,0.77)

0.87

(0.74,0.967)

0.74

(42/57)

0.79

(15/19)

0.71

(27/38)

24.74

 frac_entropy

0.74

(0.61,0.87)

0.88

(0.73.1.00)

0.55

(0.39,0.71)

0.70

(40/57)

0.62

(23/37)

0.85

(17/20)

3.51

 frac_skewness

0.72

(0.58,0.86)

0.54

(0.35,0.73)

0.90

(0.81,1.00)

0.74

(42/57)

0.82

(14/17)

0.70

(28/40)

0.52

PTEA

 frac_mean

0.65

(0.50,0.79)

0.62

(0.42,0.81)

0.65

(0.48,0.81)

0.63

(36/57)

0.59

(16/27)

0.67

(20/30)

27.29

clear_t2_margin

0.67

(0.55.0.79)

0.73

(0.54,0.88)

0.61

(0.42,0.77)

0.67

(38/57)

0.61

(19/31)

0.73

(19/26)

0.44

ETA

 Dfast_skewness

+clear_t2_margin

0.76

(0.63,0.89)

0.77

(0.62,0.92)

0.68

(0.48,0.84)

0.72

(41/57)

0.67

(20/30)

0.78

(21/27)

0.44

 Dslow_entropy

+clear_t2_margin

0.76

(0.63,0.89)

0.65

(0.46,0.85)

0.81

(0.68,0.94)

0.74

(42/57)

0.74

(17/23)

0.74

(25/34)

0.54

 frac_mean

+clear_t2_margin

0.76

(0.63,0.89)

0.50

(0.31,0.69)

0.94

(0.84,1.00)

0.74

(42/57)

0.87

(13/15)

0.69

(29/42)

0.61

 frac_entropy

+clear_t2_margin

0.78

(0.66,0.90)

0.77

(0.62,0.92)

0.71

(0.55,0.87)

0.74

(42/57)

0.69

(20/29)

0.79

(22/28)

0.49

 frac_skewness

+clear_t2_margin

0.79

(0.67,0.91)

0.81

(0.65,0.92)

0.71

(0.55,0.87)

0.75

(43/57)

0.70

(21/30)

0.81

(22/27)

0.42

PTEA

 frac_mean

+clear_t2_margin

0.75

(0.62,0.88)

0.85

(0.69,0.96)

0.58

(0.42.0.74)

0.70

(40/57)

0.63

(22/35)

0.82

(18/22)

0.36

  1. HGG: high-grade glioma; SBM: solitary brain metastasis; ETA: enhanced tumor area; PTEA: peritumor edema area. AUC: area under the curve; PPV: positive predictive value; NPV: negative predictive value. 95% CI: 95% confidence interval; TN: true negative; TP: true positive; N: negative; P: positive.
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